Eccleston ME, Micallef JV, Method for the enrichment of cell free nucleosomes.

Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.

Belgian Volition SPRL, Singapore Voliton Pte Ltd October 21, 2016: US20190064184


Eccleston ME, Micallef JV, Method for detecting nucleosomes containing histone modifications and variants.

Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.

Belgian Volition SPRL, Singapore Voliton Pte Ltd October 21, 2016: US20190064183


Eccleston ME, Herzog M: Method for anlysing nuclease hyper sensitive sites HyperGenomics PTE Ltd. April 13, 2016: WO 201666530


Micallef JV, Herzog M, Eccleston ME: Method for the enrichment of circulating tumor DNA. Singapore Voliton Pte Ltd October, 29 2015: WO 2016067029


Eccleston ME: Method for detecting histone modifications in nucleosomes. Singapore Volition Pte Ltd Sept, 27, 2014: WO 2014131841 A1   


Micallef JV, Eccleston ME, Herzog M: Method for detecting nucleosome adducts. Singapore Volition Pte Ltd June, 13, 2013: WO 2013084002


Eccleston ME, Vainkiia S, Morris GS Medical use. ValiRx PLC November, 1 2012: W02013064830


Eccleston ME, Vainkiia S, Morris GS, Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis. ValiRx PLC  November, 11 2011: GB2496135B


Micallef JV, Eccleston ME: Method for detecting the presence of a gynaecological growth. Singapore Volition Pte Feb, 2 2012: WO 2012/013955


Eccleston ME: Aqueous dispersable enteric coating composition with permeation enhancement properties. Kuecept, Nov 10 2010: GB 1018965.2


Soper PD, Miladinov VD, Amarista JA, Smith I, Elleman C, Taylor Mark, Slater NKH, Eccleston ME: Degradable chewing gum. Cadbury Adams USA May, 29 2012: CA 2656244; Jan, 6 2010: CN 200880006043; Apr, 22 2009: EP2048967; Aug, 28 2008: WO 2008/103816


Slater NKH, Eccleston ME: Hypercoiling polymers and their use in cellular delivery. Univ Cambridge Tech, Aug 31 2005: EP1567194; Jun 24 2004: WO 2004/052402; Dec 2 2003 PCT/GB2003/005262.


Eccleston ME and Slater NKH. Biocompatible polymer release system. May 25 2005: Application no. GB20050010654 20050525

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